One is that gambling-related losses and other adverse consequences result in depression. In severe addiction, people also go through withdrawal—they feel physically ill, cannot sleep and shake uncontrollably—if their brain is deprived of a dopamine-stimulating substance for too gmbling.
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So far we've talked about only one reel, though most slots have three or five, and each reel is actually weighted differently. From them we can see that the principles are exactly as I described.
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It has been almost a year since I even entered a casino, and almost two since I actually placed a bet.